|
KMID : 0363819920260010116
|
|
Korean Journal of Nuclear Medicine
1992 Volume.26 No. 1 p.116 ~ p.123
|
|
|
Distribution of 123I, 99mTc-Human Polyclonal Nonspecific IgG and 67Ga-Citrate in Abscess bearing Mice
|
|
Wee Sup Chung/Sang Moo Lim Kwang Sun Woo
Ok Doo Awh/Yong Sup Seo and Jong Doo Lee
|
|
|
Abstract
|
|
|
123I has ideal half life of 13 hours, suitable 159 keV gamma energy for imaging, and easy labeling methods. In Korea Cancer Center Hospital, 123I has been produced by MC-50 cyclotron. The purpose of this study is looking for good labeling
condition
of
123I and 99mTc to nonspecific human polyclonal IgG, and comparing these with 67Ga-citrate in the abscess bearing mice. Human polyclonal nonspecific IgG was labeled with 0.2 M phosphate buffer added 123I by chloramine T method. Human polyclonal
nonspecific IgG was labeled with 99mTc-gluconate after activation with β-mercaptoethanol. In the abscess bearing mice, the radioactivity in the abscess was higher in 24 hours than 6 hours after injection. In the abscess, 123I nonspecific IgG had
higher
uptake than 99mTc-IgG or 67Ga-citrate. There was no significant difference in absecess uptake of 123I-IgG among 24, 72, 120 hours abscess age. Further clinical researches with 123I-nonspecific IgG, and other immunoscintigraphies using 123I are
expected.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
 
|